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Friday, June 17, 2016

The Mentor



He began shaping my life when I was seventeen. My uncle had told him I wanted to be a doctor. Around midnight a few weeks later I was awakened. “There has been a terrible accident. A man is badly hurt. Do you want to help in surgery?”

Gentle reader entertain conjecture of a time unburdened by paper work, a time free of medical malpractice suits, a time when physicians not the government or insurance companies determined what was best for the patient, a time when a good history and physical examination preempted diagnostic tests. Contemplate when a simpler time rendered medicine fun and fulfilling. 

The era you have imagined had no pagers, no cell phones, no fax machines, no computers, no copiers, and no highway patrol with radar guns. The roads were narrow and poorly marked. The cars had no seat belts.

Under this veil of simplicity a middle-aged man taking a curve in a country road too fast was thrown from his car. A telephone poll made him a wishbone. He entered the operating room with a ripped pelvis, two fractured hips, a ruptured spleen and assorted other injuries considered major on an ordinary Saturday night.

That man’s misadventure introduced me to the mystery, majesty, and magic of surgery. Except for back-seat-of-the-car moon flooded nights that surgical experience was the most fun I had as a teenager.

After that I worked as his surgical assistant for four summers. In addition to the routine gall bladders, appendectomies, and bowel and bladder surgery, we also repaired abdominal aneurisms, patched those gored by bulls, thrown from horses, flipped by tractors, bit by mules, and hit over the head with beer bottles.

I went with him on house calls. I sat up with him at night watching over gravely ill patients. I was there when he told the family that their loved one had inoperable cancer and when we visited the homes of those who had died. I helped with autopsies and worked in his lab. By the time I was in medical school I had seen and done more than a first year surgical resident.

His hands were small but powerful and steady, always steady.  He worked methodically and meticulously. Like a chess master he had five or six moves planned ahead. He was always on the offensive, defeating disease, death, and destruction. He never hurried yet he finished his cases in record time. I never saw him flustered or tired. After a long night of trauma surgery he was eager to start on the scheduled gall bladders and hernias.

I was not blinded to his faults. He was sloppy. Each new day his hair competed with his clothes for most rumpled. He slumped. Slurred his speech. Chain-smoked. He burped and scratched at the most inopportune times. His deficiencies would have rendered Emily Post speechless.

Although he pioneered several surgical techniques his empirical approaches remained unknown because he was the least of self-promoters, if that’s a fault. Grimes county citizens and those that lived beyond had no idea that a surgical Michelangelo lived among them.

Of all those professional experiences that are a pleasure to recall my time with Leonard loom largest. He taught the character and skills of a good physician. He was a modest, kind gentlemen most informal in his daily contacts beloved by just about everyone who looked forward to his visits that offered encouragement, optimism and hope to all he met. To relieve suffering and to heal the sick—that was Leonard’s work.

Memory can be a perpetual stimulation for living life well. A yearning for past experiences can be relieved by enthusiasm for things yet undone.



Monday, June 13, 2016

The Way We Were


He painted the way we were. His warm humor, images of daily events made poignant, the ability to reflect the heart and soul of 20th century America made us pause and ponder: A boy with pants pulled halfway down studying a framed medical degree hung on the wall while the doctor prepares to give him an injection; a little girl beating disgruntled boys in marbles; a young man anticipating the excitement of new discoveries, his father pondering the past. These illustrations stimulate enduring feelings that represent the heart of us all. 



Most Millennials and those younger are unfamiliar with Norman Rockwell (1894-1978) while older generations rank him with baseball, apple pie and Chevrolet. He painted nearly 4000 images, including 800 magazine covers—322 for the Saturday Evening Post—and ad campaigns for more than 150 companies.

He painted common places, common values, common feelings that moved beyond the trite and banal encouraging us, bringing us hope for the common man, inspiring us toward a better life. He moved beyond kitsch, beyond the old-fashioned to seal the American way that senoirs find a pleasure to recall. 



Troubled that he was an anomaly among leading artists of his day—Paul Cezanne, Edgar Degas, Matisse, Pablo Picasso he briefly studied cubism, surrealism, fauvism in Paris. He returned to New England convinced that painting from the heart was better than painting for art critics.


Blessed with keen observation, enamored by personal interaction, Rockwell summed up a story in a single frame inspiring filmmakers of our day. In the film Empire of the Sun a young boy is put to bed by loving parents inspired by Rockwell’s Freedom from Fear painting. American Graffiti is a montage of Rockwell paintings enlivened on film. Forest Gump has a scene that re-creates Rockwell’s Girl with a Black Eye with young Forrest in place of the girl. 

Rockwell’s  keen sense of how people interact enabled him to  incorporate the larger narrative of world events into a narrowly focused microcosm of community, family and nation, an idealized American that has become a faded canvas in the 21st century.




Saturday, June 11, 2016

Rexulti: A New Improved Abilify

Rexulti (brexpiprazole) differs from Abilify (aripiprazole) in several ways. Both medications are D2 partial agonist. This property reduces dopamine output when dopamine concentrations are high thus reducing psychotic symptoms and increases dopamine output when dopamine concentrations are low thus improving mood symptoms.

In contrast to Abilify, however, Rexulti has less intrinsic activity at D2 receptors thus reducing the chance for akathisia—motor restlessness­ and other extra pyramidal symptoms (EPS) such as muscle stiffness, spasms, tremor and jerky movements. Clinical trials confirm that Rexulti has a much lower incidence of akathisia and other motor side effects than Abilify.

In addition Rexulti has more potent serotonin 5HT2A antagonism than Abilify providing antipsychotic and antimanic activity with a more auspicious side effect profile. As a more potent serotonin 5-HT1A partial agonist Rexulti may prove to be a more suitable choice for adjunctive treatment for major depression than Abilify.

The recommended starting dose for Rexulti as adjunctive treatment for Major Depressive Disorder is 0.5 mg or 1 mg daily for one week with an increase to a 2 mg target dose by the second week. The maximum adjunctive dose is 3 mg daily.  With a 91-hour half-life steady state concentration is attained in approximately 2 weeks. 

Akathisia remains the most common side effect of Rexulti but at a much lower rate than found with Abilify. 10% of patients on Rexulti experienced mild weight gain compared to 4% with placebo. There were no clinically relevant changes in lipid profiles or other metabolic parameters. Effects on prolactin levels were minimal. Rexulti does not appear to lengthen the ECG QTc interval. In a 52-week maintenance study the discontinuation rate due to adverse events was less for the Rexulti treated group than the placebo treated group.

Thursday, February 18, 2016

I Can

I can:

  • Respect myself
  • Develop my gifts and talents
  • Cultivate a healthy marriage 
  • Hope
  • Love
  • Enjoy
  • Become a critical thinker
  • Honor my body through daily exercise and a reasonable diet
  • Be enthusiastic about life
  • Cultivate healthy relationships
  • Avoid negative people
  • Control my impulses
  • Develop frustration tolerance
  • Delay gratification
  • Do first things first
  • Praise God daily
  • Live life with liveliness
I can if I only will

Monday, January 11, 2016

Refined Insults for Politicians


Instead of the puerile codswallop politicians inflict upon us they might consider modifying these cosmopolitan insults :

  • A member of Parliament to Disraeli:"Sir, you will either die on the gallows or of some unspeakable disease.” "That depends, Sir," said Disraeli,"whether I embrace your policies or your mistress."
  • He had delusions of adequacy.----Walter Kerr
  • He has all the virtues I dislike and none of the vices I admire.--- Winston Churchill
  • He has no enemies, but is intensely disliked by his friends.----Oscar Wilde
  • I am enclosing two tickets to the first night of my new play; bring a friend, if you have one.----George Bernard Shaw to Winston Churchill
  • Cannot possibly attend first night, will attend second.... if there is one.----Winston Churchill, in response
  • He is a self-made man and worships his creator.----John Bright
  • I've just learned about his illness. Let's hope it's nothing trivial.----Irvin S. Cobb
  • He is not only dull himself; he is the cause of dullness in others.----Samuel Johnson
  • He is simply a shiver looking for a spine to run up.----Paul Keating
  • To avoid being called a flirt she always yielded easily.----Charles, Count Talleyrand
  • Why do you sit there looking like an envelope without any address on it?----Mark Twain
  • His mother should have thrown him away and kept the stork.----Mae West
  • Some cause happiness wherever they go; others, whenever they go.-----Oscar Wilde
  • He was like the pure driven snow but he drifted----modification of a Mae West comment
  • Statistics are like a bikini: Exciting in what they reveal, crucial in what they hide. 
  • I once sent a dozen_______ (Republicans/Democrats) an email "flee at once, all is discovered." They all left town immediately----modification of a Mark Twain comment
  • If you feed a starving dog he will not bite you. This is the principle difference between a dog and a___________(Republican/Democrat)----modification of Mark Twain comment
  • Presidential campaigns have become so expensive it costs a billion dollars to lose.----modification of a Will Rogers comment
  • Campaigns guarantee the we have the best President money can buy.----modification of a Will Rogers comment
  • Democracy ensures that we get the leaders we deserve.----modification of a Winston Churchill comment